Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology?

Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology?

Blog Article

Abstract Mammalian organs comprise a variety of cells that interact with each other and have distinct biological roles.Access to evaluate and perturb intact biological systems at the cellular and molecular levels is essential to fully understand their functioning in normal and diseased conditions, yet technical limitations have constrained most Waxing Kits research to small pieces of tissue.Tissue clearing and optogenetics can help overcome this hurdle: tissue clearing affords optical interrogation of whole organs at the molecular level, and optogenetics enables the scalable control and measurement of cellular activity MAGNESIUM BISGLYCINATE PLUS with light.In this Q&A, we delineate recent advances and practical challenges associated with these two techniques when applied body-wide.